Phyllaemblicin B is a substance found in amla herb
Phyllaemblicin B inhibits Coxsackie virus B3 induced apoptosis and myocarditis.
Antiviral Res. 2009. Jinan University Guangdong, Guangzhou, China; National Engineering Research Center of Genetic Medicine, Guangdong, Guangzhou, China.
Coxsackie virus B3 (CVB3) is believed to be a major contributor to viral myocarditis since virus-associated apoptosis plays a role in the pathogenesis of experimental myocarditis. In this study, we investigated the in vitro and in vivo antiviral activities of Phyllaemblicin B, the main ellagitannin compound isolated from Phyllanthus emblica, a Chinese herb medicine, against CVB3. Herein we report that Phyllaemblicin B inhibited CVB3-mediated cytopathic effects on HeLa cells. In an in vivo assay, treatment with Phyllaemblicin B reduced cardiac CVB3 titers, decreased the activities of LDH and CK in murine serum, and alleviated pathological damages of cardiac muscle in myocarditic mice. Moreover, Phyllaemblicin B clearly inhibited CVB3-associated apoptosis effects both in vitro and in vivo. These results show that Phyllaemblicin B exerts significant antiviral activities against CVB3. Therefore, Phyllaemblicin B may represent a potential therapeutic agent for viral myocarditis.
Novel sesquiterpenoids from the roots of Phyllanthus emblica.
J Nat Prod. 2001. Faculty of Pharmaceutical Sciences, Nagasaki University, Bunkyo-Machi, Nagasaki , Japan.
Three novel bisabolane-type sesquiterpenoids, phyllaemblic acids B and C and phyllaemblicin D, together with two new phenolic glycosides, 2-carboxylmethylphenol 1-O-beta-D-glucopyranoside and 2,6-dimethoxy-4-(2-hydroxyethyl)phenol 1-O-beta-D-glucopyranoside, were isolated from the roots of Phyllanthus emblica.